Zekun Wang, Ruofei Zhang, Y. C. Hu, Qile Song, Xiaoyan Fu, Yifan Wang, Meizhu Chen, Kelong Fan, Cundong Fan, Dongdong Sun
@MM). Both in vitro and in vivo experiments confirmed that the dual mechanism, SOD2 activation and Hmox1 silencing, effectively restored mitochondrial function, attenuated ferroptosis, and significantly improved cardiac function in a rat model of chronic heart failure. Collectively, this study proposes a novel ferroptosis-targeted therapeutic strategy based on a biomimetic chiral nanozyme, offering new insights and promising therapeutic potential for the treatment of DOX-induced cardiotoxicity.