Mitra Pirhaghi, Fatemeh Mamashli, Bagher Davaeil, Mahya Mohammad-Zaheri, Zahra Mousavi-Jarrahi, Jörg Tatzelt, Ali Akbar Saboury
preparations and patient-derived brain samples. We further explore the impact of mutation and post-translational modifications-such as truncation and phosphorylation -on α-Syn structure and the unique polymorphs they induce. The article underscores the biological and pathological relevance of α-Syn polymorphism, highlighting how different structural strains may underlie the structural and pathological heterogeneity observed in synucleinopathies. Understanding the mechanisms driving polymorph formation is critical for deciphering disease progression and developing targeted therapeutic strategies.