Minyong Peng, Menglin Nie, Yida Cao, Qiulei Liu, Chenxu Xing, Xiaorui Li, Zhiyuan Wu, Wayne W Zhang
INAA microbiology is geographically polarized, and culture yield remains incomplete across sampling strategies. These findings support region-aware empirical therapy, routine blood and tissue sampling with antibiotic-timing documentation, and pathogen-stratified registries and guidelines.
OBJECTIVE: Infective native aortic aneurysm (INAA) is a rare, fatal vascular infection, but its microbiology has been less synthesized than repair strategy. We assessed bacterial spectrum, culture yield, concurrent infectious foci, and microbiology-related mortality risk.
METHODS: We systematically reviewed studies published to November 2024. The primary meta-analysis included 79 studies with 3,835 patients; 232 culture-confirmed case reports or small series (258 patients) were used only for descriptive pathogen mapping. Proportions were pooled with random-effects logit models, and hazard ratios (HRs) on the log-HR scale.
RESULTS: The descriptive microbiology dataset included 4,093 patients, 2,609 with confirmed bacterial etiology. Salmonella was the leading genus globally (30.6%), followed by Staphylococcus (25.6%) and Streptococcus (11.8%). Staphylococcus predominated in developed countries (30.8%), whereas Salmonella dominated developing countries (59.0%) and China (60.6%). Any microbiological detection was achieved in 64.9% (95% CI, 60.1-69.4%; I2=82.0%). Blood culture, aortic tissue, preoperative, and intraoperative sampling positivity were 52.6%, 57.2%, 51.4%, and 61.4%, respectively. The most frequent concurrent foci were gastroenteritis (12.0%), spondylodiscitis (11.7%), urinary tract infection (8.6%), endocarditis (7.0%), and pneumonia (6.8%). Non-Salmonella-positive culture was associated with higher mortality (HR, 1.65; 95% CI, 1.15-2.36); negative culture, Salmonella-positive culture, and positive blood culture were not statistically significant.
CONCLUSIONS: INAA microbiology is geographically polarized, and culture yield remains incomplete across sampling strategies. These findings support region-aware empirical therapy, routine blood and tissue sampling with antibiotic-timing documentation, and pathogen-stratified registries and guidelines.