Liliane Zillner, Mirjam G. Wild, Michaela M. Hell, Harald Herkner, Elmar Kühn, Tanja K. Rudolph, Thomas Walter, Lenard Conradi, Andreas Zierer, Francesco Maisano, Marco Russo, Fabrizio Rosati, Andrea Colli, Miguel Piñón, David Reineke, Gaby Aphram, Tillmann Kerbel, Christophe Dubois, Jörg Hausleiter, Ralph Stephan van Bardeleben, Markus Mach, Iuliana Coti, Christian Loewe, Daniel Zimpfer, Alfred Kocher, Martin Andreas
BACKGROUND: Transcatheter mitral valve replacement (TMVR) is a preferred interventional option for high-risk patients with severe mitral regurgitation who are ineligible for transcatheter edge-to-edge repair. However, the role of annular dimensions in risk stratification has been marginally explored in this distinct anatomical setting with preserved native leaflets in patients with varying degree of myocardial damage. METHODS: This subanalysis of the multicenter TENDER registry (NCT04898335) included 145 TMVR patients. Preprocedural 4D-computed tomography-derived annular dimensions were evaluated for associations with cardiac and all-cause mortality. RESULTS: ; P = .022; odds ratio, 1.005, P = .030). CONCLUSIONS: Larger annular dimensions and greater annular area loss may predict 1-year cardiac death. Possible mechanisms include impaired left ventricle filling, artificial inflow-related outflow tract obstruction, and limited reverse remodeling. Comprehensive annular assessment may also enhance patient selection for future transseptal TMVR systems.