Valine Metabolism in Cardiovascular Disease: Mechanistic Insights and Translational Perspectives.

orating evidence from clinical studies, experimental models, and systems-level analyses, we underscore the central role of valine metabolism in cardiac dysfunction and disease progression. Finally, we evaluate emerging therapeutic strategies targeting valine metabolic pathways, including dietary modulation and enzyme-based interventions, and outline major challenges that must be addressed to translate these approaches into clinical practice. Overall, this review examines the emerging evidence positioning valine metabolism as a potential metabolic hub connecting mitochondrial dysfunction with cardiovascular pathology, while acknowledging that causality remains incompletely established and that valine also serves essential physiological functions. Moreover, this review also underlines its potential as a target for precision diagnostics and metabolic therapy in CVD.