Karen Rebouças Nascimento, Pedro Brivaldo Viana da Silva, Caroline Giacomelli Soares, Ana Caroline de Melo Modesto, Anna Beatriz Moreira da Silva Ribeiro, Ícaro Alves Cavalcante Leite de Oliveira, Debora Preceliano de Oliveira, João Paulo Fabi
Pectins are a family of plant polysaccharides with complex structures whose significance extends beyond their established function as food texture modifiers. These compounds are directly relevant to human health, and their impact is influenced by structural diversity. The chemical composition of pectins varies according to botanical origin and is shaped by extraction and modification processes. Such structural differences determine both technological functionality and a range of bioactive properties, establishing pectins as potent dietary fibers with systemic health effects. Modified pectins exhibit immunomodulatory and anticancer activities through mechanisms including receptor interactions and modulation of key signaling pathways. In vivo studies further demonstrate their roles in regulating metabolism and in supporting gut barrier integrity. A critical aspect of pectin bioactivity involves promoting symbiotic interactions within the gut microbiota, increasing microbial diversity, and stimulating the production of beneficial metabolites, including short-chain fatty acids. Translational research, including clinical trials, has confirmed practical benefits for gastrointestinal management and metabolic health, and has highlighted the utility of pectins as adjuvants in pharmaceutical and nutritional formulations. This chapter highlights the link between pectins and the intersection of food science, nutrition, and biomedicine, emphasizing their potential as multifunctional ingredients for innovative health strategies.