Structural characterization and drug release kinetics of naproxen sodium loaded gum acacia grafted poly N N dimethylacrylamide CoFe2O4 nanocomposite hydrogels

Naproxen (NS) is demonstrated as an anti-inflammatory agent for the reduction of various types of pain. The main issue associated with naproxen is that it creates gastrointestinal problems as side effects. To alleviate this side effect, smart hydrogels are employed as carriers for naproxen, mimicking the passage of naproxen through the stomach and ensuring its slow release in the intestine. In this work, Gum acacia-grafted-poly(N,N-dimethylacrylamide)/CoFe 2 O 4 (GADMA CF) nanocomposite hydrogel was applied for the releasing study of NS. The synthesized materials were well characterized. NS loaded to GADMA CF-0 and GADMA CF-50 hydrogels using the swelling diffusion method. The release study was conducted in three different media. It was observed that 82.39% and 84.83% of NS were released by GADMA CF-0 and GADMA CF-50 under basic conditions, respectively.