An overview on synthetic aspects and biological activity profiles of hydrazone derivatives

In the realm of medicinal chemistry, hydrazide-hydrazones represent a versatile class of compounds that have attracted significant attention due to their structural flexibility with respect to molecular design and wide-ranging biological activities. Their characteristic azomethine linkage imparts both synthetic adaptability and diverse pharmacological potential. Consequently, hydrazones are present in numerous bioactive compounds with pharmaceutical applications. Among their diverse biological properties, antimicrobial, anticancer and antioxidant activities are often the focus of research. This paper provides an overview of synthetic aspects and their pharmaceutical potential, as documented over the past six years, thereby emphasizing recent developments in this class of compounds. This review may also serve as valuable resource for the design and synthesis of new hydrazones exhibiting a range of biological activities.