Yingkang Huang, Xiangcheng Zhu, Jinhong Zhou, Henan Li, Wei Zhang, Danyang Shen, Ziyan Huang, Tianbo Zhang, Lin Zhuang, Lei Qin, Xiaofeng Xue, Yunjie Lu
With the advancement of hydrogel technology, increasing attention has been drawn to hydrogel microspheres (HMs) due to their versatile biomedical applications. HMs play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. Composed of diverse biobased materials and fabricated through various preparation methods, HMs offer unique structural and functional advantages. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications. Their therapeutic potential across multiple disease contexts is highlighted, and emerging trends and challenges are discussed. By consolidating current knowledge, this work aims to inspire further research and accelerate the clinical translation of HMs.