Yarlini Vipulanandan, Claudette Poole
Hepatitis B virus is a well-known infectious etiology of acute and chronic liver disease worldwide. Notably, 90% of children infected with hepatitis B in infancy develop chronic infection and subsequent progressive liver disease, including cirrhosis and hepatocellular carcinoma. Significant reduction in perinatal transmission in the United States (US) was seen after implementation of universal infant vaccination 30 years ago, as well as dramatic reductions in HBV incidence across Asia, coinciding with widespread hepatitis B vaccination. However, with ongoing changes to federal vaccine guidance and a steady rise in vaccine hesitancy, a comprehensive understanding of the epidemiology, transmission, screening, and prevention of hepatitis B remains important for pediatric health care providers.