Yunyun Gao, Guoxing Zhang, Chengrui Wang, Hao Xu, Zhanhui Yu, Shunyao Jiang, Yong-Xin Liu
The rapid expansion of multi-omics data has created an increasing demand for accessible and reproducible platforms for integrative analysis. Here, we present Wekemo Bioincloud 2026, a comprehensive upgrade of the original platform, providing 41 standardized workflows (expanded from 22) across nine analytical categories, including a newly introduced correlation analysis module for cross-omics association studies. Visualization capabilities have been substantially expanded to 126 tools (from 65), incorporating artificial intelligence (AI)-guided parameter selection and automated image interpretation to enhance data exploration and result interpretability. In addition, Wekemo Bioincloud 2026 integrates an AI-powered research platform that supports the full research lifecycle, including automated literature synthesis, hypothesis generation, intelligent question answering, experimental design, and journal recommendation. Together, these advances reduce technical barriers, improve reproducibility and interpretability, and enable end-to-end AI-assisted multi-omics research. The platform is freely accessible at https://www.bioincloud.tech/ and supports a broad range of biological and biomedical applications.