Room‐Temperature C( <i>sp</i> ² )N Bond Formation Using Pd, Cu, and Ni Catalysts

Transition metal‐catalyzed C( sp 2 )–N cross‐coupling is a vital strategy in organic synthesis, enabling the efficient formation of N‐ aryl amines as key intermediates in pharmaceuticals, agrochemicals, and biologically active molecules. Precise control of reaction temperature is critical, as it significantly influences both product yield and the formation of byproducts. Conducting C( sp 2 )–N cross‐coupling at room temperature offers notable advantages, including cost‐effectiveness, enhanced safety, and reduced environmental impact. This review summarizes literature from 1983 to 2025, highlighting transition metal‐catalyzed C( sp 2 )–N cross‐coupling reactions and primarily involving palladium, copper, and nickel catalysts performed under mild, room‐temperature conditions. The review underscores the broad utility of these reactions across medicinal, agricultural, and industrial domains.