Oluwafemi Adebayo Oyewole, Abdulrazaq Izuafa, Ishola Amirat Ayomide
ABSTRACT The escalating demand for sustainable and health‐conscious food preservation strategies has positioned microbial‐derived compounds at the forefront of contemporary food science research. These bioactive metabolites encompassing bacteriocins, antibiotics, antifungal agents, organic acids, and bioactive enzymes demonstrate remarkable efficacy in suppressing foodborne pathogenic microorganisms and minimizing spoilage‐related losses. Beyond conventional preservation applications, microbial metabolites serve diverse functions across pharmaceutical, agricultural, and biotechnological sectors, including their roles as natural preservatives, therapeutic agents, fermentation catalysts, and biocontrol agents. Recent advances in strain engineering and synthetic biology have expanded the technological capacity to optimize microbial strains for enhanced metabolite yield, improved stability, and industrial‐scale feasibility, thereby presenting economically viable alternatives to synthetic chemical preservatives. The scientific community continues to address critical barriers including production efficiency, regulatory harmonization, consumer perception, and the concerning emergence of antimicrobial resistance. This manuscript synthesizes current knowledge on microbial‐derived natural products, elucidating their mechanistic pathways in food preservation and outlining future directions for sustainable food safety innovation. The evidence indicates substantial potential for these eco‐friendly bioactive compounds to address multifaceted food security challenges while promoting human and environmental health simultaneously.