Xianbo Shen, Yang Zhou, Shuangyun Luo, Zhihao Wang, Qiang Wang, Zhigang Ye, You Peng, Jie Cheng
ABSTRACT The rise of green chemistry enables remarkable progress in alcohol selective oxidation technology, which employs water as the reaction media and oxygen as the oxidant. However, the low solubility of organic compounds and oxygen in water causes severe mass transfer resistance, thus significantly impairing aqueous‐phase reaction efficiency. To address this issue, a number of thermoresponsive amphiphilic fluorinated polymers are developed. Nanoreactors self‐assembled from these polymers were constructed, with C‐F moieties integrated into the polymer backbones. This combined modification notably enhances the solubility of both organic substrates and oxygen in aqueous systems, which speeds up the reaction rate of selective alcohol oxidation. Furthermore, after the reaction, these nanoreactors can be easily recovered via simple heating and retain high catalytic activity even after five consecutive reuse cycles. This work suggests a novel approach to intensifying gas–water–oil multiphase reactions and provides a fresh viewpoint for creating environmentally safe reaction systems.