Abstract This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care, and the ramifications of AD for family caregivers, the dementia workforce, and society. An estimated 7.4 million Americans age 65 and older live with clinical Alzheimer's dementia today. This number could increase to 13.8 million by 2060, absent medical breakthroughs that prevent or cure AD. Official AD death certificates recorded 116,022 deaths from AD in 2024. Alzheimer's disease was officially listed as the sixth‐leading cause of death in the United States in 2024 and the fifth‐leading cause of death among Americans age 65 and older. Between 2000 and 2024, deaths from stroke, heart disease, and HIV decreased, whereas reported deaths from AD increased 134%. More than 12 million family members and other unpaid caregivers provided an estimated 19.6 billion hours of care to people living with Alzheimer's or other dementias in 2025. Unpaid dementia caregiving was valued at $446.3 billion in 2025. Its costs, however, extend to unpaid caregivers’ increased risk for emotional distress and negative mental and physical health outcomes. Health care professionals and the broader community‐based workforce are involved in diagnosing, treating, and caring for people living with dementia. However, the United States faces growing shortages across different segments of the dementia care workforce, driven in part by the rising number of people living with dementia. Therefore, targeted programs and care delivery models will be needed to attract, better train, and effectively deploy health care and community‐based workers to provide dementia care. Average per‐person Medicare payments for services to beneficiaries age 65 and older living with AD or other dementias are nearly three times as great as payments for beneficiaries without these conditions, and Medicaid payments are more than 22 times as great. Total payments in 2026 for health care, long‐term care, and hospice services for people age 65 and older with dementia are estimated to be $409 billion. The Special Report examines Americans' views on brain health, the habits they link to it, their current practices, and how they want to receive support.