Wei Wang, Zhening Liu, Mengjun Li, Judun Zheng, Rui Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jian Yu, Meijia Pan, Fengkuan Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao
Abstract The recent monkeypox outbreak is garnering attention, but early warning and treatment mechanisms are lacking. Owing to its rapid spread and high death rate, monkeypox must be prevented and controlled immediately. An advanced early warning system for monkeypox prevention and control is provided through aggregation‐induced emission luminogen (AIEgen)‐active monitoring and precision photodynamic therapy (PDT). This system are developed by combining a sprayable AIE@LD with a commercial liquid dressing (LD) and a pyridine‐substituted benzothiadiazole derivative possessing AIEgen properties. In vivo tests revealed that 1 min of low‐power white light PDT at 5 mW cm − 2 promoted viral eradication and lesion healing within one week. The system comprises dual optical channels that incorporate smartphone image recognition software and a cloud platform, combining image analysis, data transmission, infection monitoring, and PDT to provide a comprehensive solution for detecting, monitoring, treating, and interrupting the transmission of monkeypox. This system can considerably reduce the medical burden of monkeypox epidemics and provide innovative ideas and technological assistance for intelligent prevention and management.