Tayyaba Akram, Bing Zhang, Gang Zhao
Abstract MXene‐polymer nanocomposite hydrogels have emerged as a transformative platform for next‐generation wearable sensors, offering an exceptional combination of mechanical robustness, high electrical conductivity, and responsiveness to diverse external stimuli. This review provides a comprehensive overview of the design strategies for MXene‐polymer networks, focusing on surface‐specific interactions such as hydrogen bonding in polyvinyl alcohol (PVA)‐MXene like systems, and π–π stacking in composites like poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT: PSS)‐MXene. These tailored interactions contribute to exceptional self‐healing capabilities and high sensitivity to pressure variations. Further a comparative framework of MXene is presented against traditional nanomaterials (graphene, carbon nanotubes, metal oxides), highlighting its superior surface functionality and solution processability. MXene‐based hydrogels demonstrate outstanding real‐world sensing performance. These capabilities have been validated in vivo studies, including continuous glucose monitoring. Innovative applications span epidermal electronics and implantable sensors. A performance matrix benchmarks MXene hydrogels against state‐of‐the‐art materials, addressing unresolved challenges such as MXene restacking, signal drift. This review provides a forward‐looking roadmap for deploying MXene hydrogels in personalized healthcare, human‐machine interfaces, and flexible wearable electronics.