Fuxiao Wang, H W Zhang, Dongyang Zhou, Xuan Tang, Yi-Xiang Wang, H Liu, X Y Wang, Yuanwei Zhang, Z L Li, Y Jiang, Qin Zhang, Xiao Chen, Yingying Jing, Ke Xu, Yun Hu, Lu Bai, Jiacan Su
Dual Renewal Strategy for Rheumatoid Arthritis Inspired by Chinese philosophy, this cover illustrates a dual-action mitochondrial renewal therapy (DAMRT) for rheumatoid arthritis. Like a lotus leaf, a folate-modified macrophage membrane precisely encapsulates healthy mitochondria and AUTAC4. This biomimetic system targets inflamed joints, delivering fresh mitochondria while degrading dysfunctional ones to effectively restore cellular metabolic homeostasis. More details can be found in the Research Article by Ke Xu, Yan Hu, Long Bai, Jiacan Su, and co-workers (DOI: 10.1002/adma.202514070).