Yao Xiao, Xu Chen, Jingnan Liao, Yi-Xiang Wang, Lili Lu, Huan Chen, Chengu Niu, Mingyuan Wang
Precision Gut Rehab via Nanosponges The cover visualizes a microscopic “cyber-repair” operation against ulcerative colitis, as developed by Mingyuan Wang and co-workers. The illustration shows intelligent, dual-pH-responsive nanosponges (CurN@I) navigating the inflamed gut. Upon activation, they precisely release therapeutic payloads to dismantle necroptosis-driving RIPK1/RIPK3 complexes (depicted as glowing red machinery being destroyed by blue data streams) and simultaneously reconstruct the damaged epithelial barrier with a reparative agent (golden mist), all under real-time CT theranostic guidance. More details can be found in the Research Article by Mingyuan Wang and co-workers (DOI: 10.1002/adma.202516297).