Microporous Annealed Particle Wound Matrix for Post-Mohs Defects: A Randomized Controlled Multicenter First-In-Human Study.

BACKGROUND: Post-Mohs surgical wounds may be painful, slow to heal, and prone to scarring. Comparative data for advanced wound care biomaterials in this setting are limited. OBJECTIVE: The aim of this study was to evaluate the safety of a flowable, synthetic, microporous annealed particle (MAP) wound matrix versus hydrocolloid dressing and explore effects on pain, wound healing, and scarring. MATERIALS AND METHODS: In this multicenter randomized study, a flowable synthetic MAP wound matrix was applied immediately after surgery and compared with a hydrocolloid dressing (control). The primary endpoint was safety. Exploratory endpoints included pain, Wound Bed Score, time to granulation, time to closure, and scarring at 6 months. RESULTS: Forty patients were randomized to receive the wound matrix (n = 26) or control (n = 14). The primary safety endpoint was met. Pain was low in both groups and numerically lower in the matrix group. The matrix group achieved a Wound Bed Scoreof 12 or greater 14 days earlier than control. Granulation and closure times were similar. Scarring scores were significantly better in the matrix group (p = .0027). CONCLUSION: The MAP wound matrix was safe, did not delay healing, improved early wound bed quality, and reduced scarring versus standard of care.