Skin-Inspired Ti3C2Tx MXene-AgNWs/Silk Fibroin Composite Film for Skin Bioelectronics and Wound Management.

Skin bioelectronics have demonstrated significant potential in healthcare monitoring and wound management. Nevertheless, developing an innovative bioelectronics-integrated wound dressing still poses a significant clinical challenge in wound management. Herein, we present a smart and flexible bioelectronics-integrated wound dressing, constructed from a skin-inspired Ti3C2Tx MXene-AgNWs/silk fibroin (MX-Ag/SF) composite film. The MX-Ag/SF composite film exhibits high breathability, conductivity, flexibility and stretchability, biocompatibility, and photothermal antibacterial properties. This makes it suitable for assembly into a versatile epidermal sensor for real-time monitoring of various human physiological signals. Furthermore, both in vitro and in vivo studies demonstrate that the MX-Ag/SF composite film significantly enhances its therapeutic efficacy in treating diabetic wounds, which is accomplished by suppressing inflammatory cell infiltration, promoting angiogenesis, enhancing re-epithelialization, stimulating collagen deposition, inhibiting bacterial growth, and effectively controlling wound infection. In addition, the MX-Ag/SF composite film functions as a novel flexible bioelectronic device for wound movement tracking or wound monitoring during wound healing process. This capability renders it highly promising for applications in skin bioelectronics for intelligent post-wound monitoring and rehabilitation motion management. This study introduces a promising approach to developing an innovative bioelectronics-integrated wound dressing, which can be applicable in skin bioelectronics for health monitoring and chronic wound management.