Enhance Electrohydrodynamic Direct‐Writing Potential in Bone Tissue Engineering: Design Innovations, Multidisciplinary Insight, and Future Direction

Abstract Over the past decade, electrohydrodynamic (EHD) direct‐writing has emerged as a transformative technique in bone tissue engineering, offering precise control over the composition, morphology, and functionality by constructing bone‐mimetic structures. This multifunctional process facilitates the production of fibers in micro‐ and nanoscale with customized integrating of diverse materials and structures for advanced research and applications in bone regeneration. The design innovations and multidisciplinary insight become indispensable as the focus shifts toward personalized medicine and reduced reliance on animal models. This review focuses on the core elements of EHD direct‐writing in bone tissue engineering, covering materials science, bioprinting, and computational biology. A detailed description of bone physiology is provided, followed by examining the observed phenomena during printing. The impact of design considerations, including biomaterial selection and structural topographic cues, on biological performance is prominently emphasized. The most relevant and recent advances related to biomedical applications in bone tissue engineering are also summarized, as well as the necessity for multidisciplinary collaboration across computational modeling, intelligent responsiveness, bone organ models, microfluidics, and cellular constructs. Future perspectives, involving biomimetics of physiological processes and artificial intelligence (AI)‐assisted approaches are discussed, along with the current gaps to advance the field further.