L. Botta, Fabio Didoné, Angela Lopez-Cortes, Adela Cañete Nieto, Emmanuel Désandes, Lisa Lyngsie Hjalgrim, Zsuzsanna Jakab, Charles Stiller, Bernward Zeller, Simon Bailey, Nathalie Gaspar, Filippo Spreafico, Sandra J. Strauss, Gemma Gatta, Kathy Pritchard-Jones, BENCHISTA Project Working Group, Joanne F Aitken, Leisa O'Neil, Danny R. Youlden, Monika Hackl, Ruth Ladenstein, Elizabeth Van Eycken, Nancy Van Damme, Beatriz de Camargo, Marceli de Oliveira Santos, Carlos Anselmo Lima, Ramos Wf, Lucrécia Aline Cabral Formigosa, Luciana Ferreira dos Santos, Claudina Agnese Casale, Gil Patrus Pena, Juliana Nativio, C. Laporte, Cristiana Santos de Menezes Miranda, Cristiane Bastos Daniel, RAIMUNDA NONATA DE PAULO, D. B Veneziano, A. De Aquino, Paulo César Fernandes de Souza, Rebeca Valentim Leite, Zdravka Valerianova, Dobrin Konstantinov, Sumit Gupta, Jason D. Pole, J. Starý, Jaroslav Sterba, Lisa Lyngsie Hjalgrim, Jeanette Falck Winther, Keiu Paapsi, B. Lacour, Emmanuel Désandes, Jacqueline Clavel, Claire Poulalhon, M. Ressing, Claudia Truenbach, Claudia Spix, Eleni T. Petridou, Evdoxia Bouka, Zsusanna Jakab, Miklós Garami, Rocco Galasso, Giuseppe Sampietro, Patrizia Piga, Marcella Sessa, M Maule, Carlotta Sacerdote, Paola Ballotari, Luigino Dal Maso, Antonina Torrisi, Rosalia Ragusa, Luca Boni, Magda Rognomi, Rosalba Amodio, Francesco Cuccaro, Donato Bruno, Antonio G Russo, Federico Gervasi, Maria L. Gambino, Elisabetta Borciani, Maria L. Michiara, L. Mangone, Gianbattista Spagnoli, Stefano Ferretti, Fabio Falcini, Eugenia Spata, Sonia Manasse, Paolo Coccia, Fabrizio Stracci, Daniela Piras, Pasquala Pinna, Francesca Bella, Adele Caldarella, Teresa Intrieri, Tiziana Scuderi, William Mantovani, Manuel Zorzi, Stefano Guzzinati, Deidre M. Murray, Tomohiro Matsuda, Kayo Nakata
Importance: Understanding the reasons for variations in population-level survival differences in childhood cancer is important to guide improvement efforts. Collaboration between population-based cancer registries (CRs) to apply the international consensus Toronto guidelines to record tumor stage at diagnosis is a key first step. Objective: To test whether survival probabilities by tumor stage vary internationally, using 6 childhood solid tumors as exemplars. Design, Setting, and Participants: The International Benchmarking of Childhood Cancer Survival by Stage (BENCHISTA) population-based retrospective cohort study included all incident cases of neuroblastoma, Wilms tumor, medulloblastoma, osteosarcoma, Ewing sarcoma of bone, and rhabdomyosarcoma diagnosed between January 1, 2014, and December 31, 2017, with 3-year follow-up for survival. A total of 73 CRs from 27 countries (23 European as well as Australia, Brazil, Canada, and Japan) constituted the dataset. Analyses were conducted from June 2023 to December 2024. Main Outcomes and Measures: Three-year overall survival (OS) by stage for each tumor type, with comparisons between countries grouped into 5 predefined European areas. Multivariable Cox and logistic models estimated each area's hazard or odds ratio of death compared with Central Europe (Austria, Belgium, France, Germany, Switzerland, and the Netherlands), adjusted by age group and stage. Results: A total of 9883 cases were included; 4452 (45%) were girls and overall median (IQR) age was 54 (22-122) months; stage completeness was 93% (9199 of 9883). Three-year OS rates were as follows: Wilms tumor, 95% (95% CI, 94%-96%); neuroblastoma, 83% (95% CI, 81%-84%); medulloblastoma, 79% (95% CI, 77%-81%); Ewing sarcoma, 78% (95% CI, 75%-80%); rhabdomyosarcoma, 77% (95% CI, 74%-79%); and osteosarcoma, 75% (95% CI, 73%-77%). Geographical variations in age-adjusted OS were found for neuroblastoma, medulloblastoma, Ewing sarcoma, and rhabdomyosarcoma. Following additional adjustment for stage, differences were no longer significant for neuroblastoma (in the UK and Ireland) and rhabdomyosarcoma (in Eastern Europe) while becoming significant for neuroblastoma in Eastern Europe (hazard ratio, 1.36; 95% CI, 1.05-1.76) and medulloblastoma in Southern Europe (hazard ratio, 1.42; 95% CI, 1.03-1.94). However, no mitigation of survival variation was observed for Ewing sarcoma in the UK and Ireland (hazard ratio, 2.06; 95% CI, 1.39-3.04) and Eastern Europe (hazard ratio, 1.87; 95% CI, 1.22-2.86) as well as for medulloblastoma in Eastern Europe (hazard ratio, 1.68; 95% CI, 1.13-2.49). Conclusions and Relevance: In this BENCHISTA cohort study of 6 solid tumors, international variation in population-level OS was associated with differences in tumor stage distribution for some cancer types and regions. Additional factors are suggested for further investigation. The results have important implications for national health systems for monitoring early diagnosis efforts and supporting collaboration between CRs and clinicians to sustain standardized use of Toronto guidelines to improve understanding of survival variation in childhood cancer.